Orotidine 5'-phosphate decarboxylase (IPR014732)

Short name: OMPdecase

Overlapping homologous superfamilies

Family relationships



Orotidine 5'-phosphate decarboxylase (OMPdecase) (EC: [PMID: 2835631, PMID: 1730672] catalyzes the last step in the de novo biosynthesis of pyrimidines, the decarboxylation of OMP into UMP. In higher eukaryotes OMPdecase is part, with orotate phosphoribosyltransferase, of a bifunctional enzyme, while the prokaryotic and fungal OMPdecases are monofunctional proteins.

Some parts of the sequence of OMPdecase are well conserved across species. The best conserved region is located in the N-terminal half of OMPdecases and is centred around a lysine residue which is essential for the catalytic function of the enzyme.

GO terms

Biological Process

GO:0044205 'de novo' UMP biosynthetic process

Molecular Function

GO:0004590 orotidine-5'-phosphate decarboxylase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.