Protein arginine N-methyltransferase PRMT7 (IPR014644)

Short name: MeTrfase_PRMT7

Overlapping homologous superfamilies

Family relationships


This entry represents protein arginine N-methyltransferase PRMT7 [PMID: 15044439].

PRMT7 can catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. It mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. It also mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. It plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. It may also play a role in embryonic stem cell (ESC) pluripotency [PMID: 15044439, PMID: 15494416, PMID: 17709427, PMID: 19110445].

GO terms

Biological Process

GO:0006479 protein methylation

Molecular Function

GO:0008168 methyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.