Family

Filoviruses glycoprotein (IPR014625)

Short name: GPC_FiloV

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Proteins in this family include the envelope glycoprotein and the pre-small/secreted glycoprotein from Filoviridae [PMID: 8437211]. The envelope glycoprotein can be cleaved into 3 chains: GP1, GP2 and GP2-delta.

GP1 is responsible for binding to the receptor(s), such as CD209 and CLEC4M, on target cells. These interactions not only facilitate virus cell entry, but also allow capture of viral particles by dendritic cells (DCs) and subsequent transmission to susceptible cells without DCs infection (trans infection) [PMID: 17005688].

GP2 acts as a class I viral fusion protein. It is responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane [PMID: 17005688].

GP1,2 peplomers mediates endothelial cell activation and decreases endothelial barrier function. It mediates activation of primary macrophages. At terminal stages of the viral infection, when its expression is high, GP1,2 down-modulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion [PMID: 17005688].

GP2delta is part of the complex GP1,2delta released by host ADAM17 metalloprotease. This secreted complex may play a role in the pathogenesis of the virus by efficiently blocking the neutralizing antibodies that would otherwise neutralize the virus surface glycoproteins GP1,2. Might therefore contribute to the lack of inflammatory reaction seen during infection in spite the of extensive necrosis and massive virus production. GP1,2delta does not seem to be involved in activation of primary macrophage [PMID: 16775318].

pre-small/secreted glycoprotein sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha. It might therefore contribute to the lack of inflammatory reaction seen during infection in spite the of extensive necrosis and massive virus production. It does not seem to be involved in activation of primary macrophages. It does not seem to interact specifically with neutrophils [PMID: 11152533, PMID: 12482654, PMID: 16051836, PMID: 15681442].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF