Alcohol dehydrogenase class III (IPR014183)

Short name: ADH_3

Overlapping homologous superfamilies

Family relationships



Class III alcohol dehydrogenases (ADH3) (EC: tend to show poor activity for ethanol among their various substrate alcohols. They catalyze the oxidation and reduction of a wide variety of substrates that include S-(hydroxymethyl)glutathione (HMGSH), S-nitrosoglutathione, and long chain primary alcohols and aldehydes [PMID: 1872853]. The enzyme was previously designated as glutathione-dependent formaldehyde dehydrogenase, as it acts as a HMGSH dehydrogenase (EC: ADH3 oxidizes HMGSH to S-formylglutathione, which is then hydrolyzed to glutathione and formate by a hydrolase [PMID: 9059641, PMID: 7484406]. S-(hydroxymethyl)glutathione can form spontaneously from formaldehyde and glutathione, and constitutes a cellular strategy for sequestering and metabolizing highly toxic formaldehyde [PMID: 12484756].

GO terms

Biological Process

GO:0006069 ethanol oxidation
GO:0055114 oxidation-reduction process

Molecular Function

GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase activity
GO:0008270 zinc ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.