DNA ligase D, ligase domain (IPR014146)

Short name: LigD_ligase_dom

Overlapping homologous superfamilies


Domain relationships



DNA repair of double-stranded breaks by non-homologous end joining (NHEJ) is accomplished by a two-protein system that is present in a minority of prokaryotes. One component is the Ku protein (see IPR009187), which binds DNA ends. The other is a DNA ligase, a protein that is a multidomain polypeptide in most of those bacteria that have NHEJ, a permuted polypeptide in Mycobacterium tuberculosis and a few other species, and the product of tandem genes in some other bacteria. This region represents the central ligase domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.