DNA ligase D, polymerase domain (IPR014145)

Short name: LigD_pol_dom

Overlapping homologous superfamilies


Domain relationships


DNA repair of double-stranded breaks by non-homologous end joining (NHEJ) is accomplished by a two-protein system that is present in a minority of prokaryotes. One component is the Ku protein (see IPR009187), which binds DNA ends. The other is a DNA ligase, a protein that is a multidomain polypeptide in most of those bacteria that have NheJ, a permuted polypeptide in Mycobacterium tuberculosis and a few other species, and the product of tandem genes in some other bacteria. This region represents the C-terminal polymerase domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.