Homologous Superfamily

Glutathione synthase, N-terminal, eukaryotic (IPR014049)

Short name: Glutathione_synthase_N_euk

Overlapping entries


This superfamily represents the N-terminal domain found in eukaryotic glutathione synthetase (EC: (GSS), a homodimeric enzyme that catalyses the conversion of gamma-L-glutamyl-L-cysteine and glycine to phosphate and glutathione in the presence of ATP. This is the second step in glutathione biosynthesis, the first step being catalysed by gamma-glutamylcysteine synthetase [PMID: 15981742]. In humans, defects in GSS are inherited in an autosomal recessive way and are the cause of severe metabolic acidosis, 5-oxoprolinuria, and increased rate of haemolysis and defective function of the central nervous system. The N-terminal domain has a 2-layer alpha/beta structure.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005524 ATP binding
GO:0004363 glutathione synthase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.