2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain (IPR013709)

Short name: 2-isopropylmalate_synth_dimer

Overlapping homologous superfamilies

Domain relationships



This is the C-terminal regulatory (R) domain of alpha-isopropylmalate synthase, which catalyses the first committed step in the leucine biosynthetic pathway [PMID: 15159544]. This domain, is an internally duplicated structure with a novel fold [PMID: 15159544]. It comprises two similar units that are arranged such that the two helices pack together in the centre, crossing at an angle of 34 degrees, sandwiched between the two three-stranded, antiparallel beta-sheets. The overall domain is thus constructed as a beta-alpha-beta three-layer sandwich [PMID: 15159544].

GO terms

Biological Process

GO:0009098 leucine biosynthetic process

Molecular Function

GO:0003852 2-isopropylmalate synthase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.