SEFIR domain (IPR013568)

Short name: SEFIR_dom

Overlapping homologous superfamilies


Domain relationships



The SEFIR domain (after SEFs and IL17Rs) is a conserved sequence segment identified in transmembrane receptors (including SEFs, IL17Rs) and soluble factors (including CIKS/ACT1) in eukaryotes and bacteria. In addition to the SEFIR sequence homology, SEFs and IL17Rs share the same architecture. Their extracellular regions are sequentially divergent but appear structurally similar to a tandem fibronectin 3 (FN3)-like domain arrangement. A single transmembrane region is followed by a high-complexity sequence region involving the SEFIR domain and a C-terminal tail that is enriched with polar residues and, sometimes, with low complexity regions [PMID: 12765832].

The SEFIR domain is related to the TIR domain. The SEFIR domain is similar to the TIR domain in length and secondary structure. The similarity between the SEFIR and TIR domains involves the conserved boxes 1 and 2 of the TIR domain that are implicated in homotypic dimerization, but there is no sequence similarity between SEFIR domains and the TIR sequence box 3 [PMID: 12765832].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles