CTNNB1 binding, N-teminal (IPR013558)

Short name: CTNNB1-bd_N

Overlapping homologous superfamilies


Domain relationships



This region tends to appear at the N terminus of proteins also containing DNA-binding HMG (high mobility group) boxes (IPR009071) and appears to bind the armadillo repeat of CTNNB1 (beta-catenin), forming a stable complex. Signalling by Wnt through TCF/LCF is involved in developmental patterning, induction of neural tissues, cell fate decisions and stem cell differentiation [PMID: 15765502]. Isoforms of HMG T-cell factors lacking the N-terminal CTNNB1-binding domain cannot fulfil their role as transcriptional activators in T-cell differentiation [PMID: 10080941, PMID: 9783587].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.