Beta-catenin (IPR013284)

Short name: Beta-catenin

Overlapping homologous superfamilies

Family relationships


Three different forms of catenin (designated alpha, beta and gamma) comprise the cytoplasmic domain of the cadherin cell-cell adhesion complex [PMID: 7945318]. Beta-catenin forms a cadherin/beta-catenin/alphaE-catenin complex that can tether the tripartite adhesion complex and regulate actin dynamics [PMID: 23739176].

This entry represents the beta catenins and homologues, plakoglobin and the Drosophila Armadillo protein [PMID: 2261639], which are implicated in cell adhesion and Wnt signalling [PMID: 9425166]. Originally identified as downstream elements (armadillo phenotype) of the Wnt signalling pathway (wingless phenotype) [PMID: 10679188, PMID: 1397690]. The beta-catenin structure has been determined [PMID: 9298899, PMID: 11136974]. Beta catenin family proteins contain several ARM repeats, sequences of approximately 50 amino acids involved in protein-protein interactions. Each repeat consists of three helices [PMID: 9298899, PMID: 11136974, PMID: 11491282], with helix 1 and 3 antiparallel to each other and perpendicular to helix 2 [PMID: 9298899, PMID: 11136974, PMID: 11491282]. A conserved glycine residue allows the sharp turn between helices 1 and 2 [PMID: 9298899, PMID: 11136974, PMID: 11491282].

GO terms

Biological Process

GO:0007155 cell adhesion

Molecular Function

GO:0045296 cadherin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.