Family

Kinetochore-associated protein Dsn1/Mis13 (IPR013218)

Short name: Dsn1/Mis13

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

This entry represents the kinetochore-associated protein Dsn1/Mis13.

In Saccharomyces cerevisiae, Dsn1 acts as essential component of the kinetochore MIND complex, which is required for the spindle checkpoint and kinetochore integrity. MIND plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules [PMID: 12455957, PMID: 14633972].

In Schizosaccharomyces pombe, Mis13 acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. It is required for correct segregation of chromosomes and for maintaining the inner centromere structure [PMID: 16079914,PMID: 17035632].

GO terms

Biological Process

GO:0051301 cell division
GO:0007059 chromosome segregation

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0000444 MIS12/MIND type complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
Pfam