Domain

Cytidine/deoxycytidylate deaminase, zinc-binding domain (IPR013171)

Short name: Cyd/dCyd_deaminase_Zn-bd

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This region contains the zinc-binding domain of cytidine and deoxycytidylate deaminase.

Cytidine deaminase (EC:3.5.4.5) (cytidine aminohydrolase) catalyzes the hydrolysis of cytidine into uridine and ammonia while deoxycytidylate deaminase (EC:3.5.4.12) (dCMP deaminase) hydrolyzes dCMP into dUMP. Both enzymes are known to bind zinc and to require it for their catalytic activity [PMID: 1567863, PMID: 8428902]. These two enzymes do not share any sequence similarity with the exception of a region that contains three conserved histidine and cysteine residues which are thought to be involved in the binding of the catalytic zinc ion.

GO terms

Biological Process

GO:0009972 cytidine deamination

Molecular Function

GO:0004126 cytidine deaminase activity
GO:0008270 zinc ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam