Organic radical enzyme activase (IPR012839)

Short name: Organic_radical_activase

Overlapping homologous superfamilies


Family relationships


This subset of the radical-SAM domain includes a number of probable activating proteins acting on different enzymes all requiring an amino-acid-centred radical. The closest relatives to this family are the pyruvate-formate lyase activating enzyme (PflA, EC:, IPR012838) and the anaerobic ribonucleotide reductase activating enzyme (IPR012837). Included within this subfamily are activators of hydroxyphenyl acetate decarboxylase (HdpA, [PMID: 15153112]), benzylsuccinate synthase (BssD, [PMID: 14735297]), gycerol dehydratase (DhaB2, [PMID: 12704244]), trans-4-hydroxy-L-proline dehydratase (pflE, [PMID: 28183913]) as well as enzymes annotated in Escherichia coli as activators of different isozymes of pyruvate-formate lyase (PFLC and PFLE) however, these appear to lack characterisation and may activate enzymes with distinctive functions. Most of the sequence-level variability between these forms is concentrated within an N-terminal domain, which follows a conserved group of three cysteines and contains a variable pattern of 0 to 8 additional cysteines.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.