Homologous Superfamily

Ribonuclease H-like superfamily (IPR012337)

Short name: RNaseH-like_sf

Overlapping entries



The catalytic domain of several polynucleotidyl transferases share a similar structure, consisting of a 3-layer alpha/beta/alpha fold that contains mixed beta sheets, suggesting that they share a similar mechanism of catalysis. Polynucleotidyl transferases containing this domain include ribonuclease H class I (RNase HI) and class II (RNase HII), HIV RNase (reverse transcriptase domain), retroviral integrase (catalytic domain), Mu transposase (core domain), transposase inhibitor Tn5 (containing additional all-alpha subdomains), DnaQ-like 3'-5' exonucleases (exonuclease domains), RuvC resolvase, and mitochondrial resolvase ydc2 (catalytic domain) [PMID: 15299518, PMID: 8696976, PMID: 12823554].

This superfamily also includes the YqgF domain, described as RNase H-like and typified by the Escherichia coli protein YqgF [PMID: 14512736, PMID: 10982859]. YqgF domain-containing proteins are predicted to be ribonucleases or resolvases based on homology to RuvC Holliday junction resolvases.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.