Flavivirus glycoprotein central and dimerisation domain (IPR011998)

Short name: Glycoprot_cen/dimer

Overlapping homologous superfamilies

Domain relationships



Flaviviruses and alphaviruses are arthropod-borne, enveloped RNA viruses that cause infections in vertebrate hosts [PMID: 15378043]. These viruses have two envelope glycoproteins (also known as 'spike' glycoproteins), one that undergoes proteolytic cleavage to prime the virus (glycoproteins M and P62 in flaviviruses and alphaviruses, respectively), and the other to mediate receptor binding and fusion (glycoproteins E and E1 in flaviviruses and alphaviruses, respectively). Glycoprotein E/E1 is comprised of three domains: domain I (dimerisation domain) is a beta-barrel, domain II (central domain) is an elongated beta-stranded and alpha-helical domain, and domain III (immunoglobulin-like domain) is an IgC-like beta-sandwich. This entry represents the intertwined central and dimerisation domains found in flaviviral glycoprotein E [PMID: 12759475] and alphaviral glycoprotein E1 [PMID: 11301009] proteins.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0046983 protein dimerization activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.