Huwentoxin-1 family (IPR011696)

Short name: Huwentoxin-1

Overlapping homologous superfamilies


Family relationships



This is a family of potent toxins that function as ion-channel inhibitors. Omega-Grammotoxin SIA is a VSCC antagonist that inhibits neuronal N- and P-type VSCC responses [PMID: 8394998]. Huwentoxin-IV, from the Chinese bird spider, is a highly potent neurotoxin that specifically inhibits the neuronal tetrodotoxin-sensitive voltage-gated sodium channel in rat dorsal root ganglion neurons [PMID: 12228241]. Hainantoxin-4, from the venom of spider Selenocosmia hainana, adopts an inhibitor cystine knot structural motif like huwentoin-IV, and is a potent antagonist that acts at site 1 on tetrodotoxin-sensitive (TTX-S) sodium channels [PMID: 12827284]. Study of the molecular nature of toxin-receptor interactions has helped elucidate the functioning of many ion-channels [PMID: 20189991].

GO terms

Biological Process

GO:0009405 pathogenesis

Molecular Function

GO:0008200 ion channel inhibitor activity

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.