Ubiquinone biosynthesis protein Coq7 (IPR011566)

Short name: Ubq_synth_Coq7

Overlapping homologous superfamilies

Family relationships



Coq7 (also known as Clk-1 and CAT5) is a di-iron carboxylate protein occuring in both prokaryotes and eukaryotes that is essential for ubiquinone biosynthesis [PMID: 8621692, PMID: 9823893]. It has been implicated in the aging process as mutations in the Caenorhabditis elegans gene lead to increased lifespan [PMID: 9020081]. Coq7 is a membrane-bound protein that functions as a monooxygenase to hydroxylate demethoxyubiquinone (DMQ or 2-methoxy-5-methyl-6-polyprenyl-1,4-benzoquinone) in the penultimate step of ubiquinone biosynthesis [PMID: 11435415]. Biochemical studies indicate that NADH can serve directly as a reductant for catalytic activation of dioxygen and substrate oxidation by the enzyme, with no requirement for an additional reductase protein component [PMID: 20923139]. This direct reaction with NADH is so far unique amongst members of the di-iron carboxylate protein family.

GO terms

Biological Process

GO:0055114 oxidation-reduction process
GO:0006744 ubiquinone biosynthetic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.