Rho termination factor, RNA-binding domain (IPR011113)

Short name: Rho_RNA-bd

Overlapping homologous superfamilies

Domain relationships

  • Cold shock domain (IPR011129)
    • Rho termination factor, RNA-binding domain (IPR011113)


The Rho termination factor disengages newly transcribed RNA from its DNA template at certain, specific transcripts. It is thought that two copies of Rho bind to RNA and that Rho functions as a hexamer of protomers [PMID: 10230401].

The Rho N-terminal domain consists of two subdomains: a three-helix bundle followed by a beta-barrel. The beta-barrel is an OB-type fold, which is found in a wide variety of single-stranded nucleic acid binding molecules that include cold shock proteins. An indented face on one side of this subdomain forms the primary RNA binding site of Rho [PMID: 12859904].

GO terms

Biological Process

GO:0006353 DNA-templated transcription, termination

Molecular Function

GO:0003723 RNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.