Cell wall hydrolase, SleB (IPR011105)

Short name: Cell_wall_hydrolase_SleB

Overlapping homologous superfamilies


Domain relationships



These enzymes have been implicated in cell wall hydrolysis, most extensively in Bacillus subtilis. For instance P50739 is expressed during sporulation in an inactive form and deposited on the cell outer cortex. During germination the enzyme is activated and hydrolyses the cortex [PMID: 10658652]. A similar role is carried out by the partially redundant P42249 [PMID: 9515903].

The sleB gene (P50739) encodes a germination-specific N-acetylmuramyl-L-alanine amidase in B. subtilis and Bacillus cereus [PMID: 10197998]. It is synthesized with a putative signal sequence and hydrolyses the spore cortex in situ, during germination. In dormant spores it exist in a mature but inactive state.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016787 hydrolase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.