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Overview
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Cross-references
p53, tetramerisation domain (IPR010991)
Short name: p53_tetrameristn
Overlapping homologous superfamilies
- p53-like tetramerisation domain superfamily (IPR036674)
Domain relationships
None.
Description
The p53 protein is a tetrameric transcription factor that plays a central role in the prevention of neoplastic transformation [PMID: 7878469]. Oligomerization appears to be essential for the tumour suppressing activity of p53. p53 can be divided into different functional domains: an N-terminal transactivation domain, a proline-rich domain, a DNA-binding domain (IPR008967), a tetramerisation domain and a C-terminal regulatory region. The tetramerisation domain of human p53 extends from residues 325 to 356, and has a 4-helical bundle fold. The tetramerisation domain is essential for DNA binding, protein-protein interactions, post-translational modifications, and p53 degradation [PMID: 11420672].
GO terms
Biological Process
GO:0051262 protein tetramerization
Molecular Function
No terms assigned in this category.
Cellular Component
No terms assigned in this category.
Contributing signatures
- PF07710 (P53_tetramer)