Domain

p53, tetramerisation domain (IPR010991)

Short name: p53_tetrameristn

Overlapping homologous superfamilies

Domain relationships

None.

Description

The p53 protein is a tetrameric transcription factor that plays a central role in the prevention of neoplastic transformation [PMID: 7878469]. Oligomerization appears to be essential for the tumour suppressing activity of p53. p53 can be divided into different functional domains: an N-terminal transactivation domain, a proline-rich domain, a DNA-binding domain (IPR008967), a tetramerisation domain and a C-terminal regulatory region. The tetramerisation domain of human p53 extends from residues 325 to 356, and has a 4-helical bundle fold. The tetramerisation domain is essential for DNA binding, protein-protein interactions, post-translational modifications, and p53 degradation [PMID: 11420672].

GO terms

Biological Process

GO:0051262 protein tetramerization

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam