Titin repeats (IPR010939)

Short name: Titin-rpts


This entry represents the 90-95 residue immunoglobulin (Ig) repeats found in invertebrate Titin.

Drosophila Titin (also known as Kettin) is an actin-binding protein functioning in both muscle and chromosome structure and elasticity [PMID: 10669599, PMID: 11062264]. It is is essential for the formation and maintenance of normal sarcomere structure of muscles and muscle tendons [PMID: 10629221]. Titin is a modular protein of 500-700kDa containing fibronectin type III (FNIII) repeats and immunoglobulin (Ig) repeats. The Ig and FNIII repeats are arranged in different patterns throughout the molecule [PMID: 10047523]. Titin also contains an elastic region rich in proline, glutamic acid, valine and lysine residues, termed the PEVK domain, and a C-terminal serine kinase domain. Titin transcripts are differentially spliced, particularly in regions encoding the tandem-Ig and PEVK domains, giving rise to many isoforms with different extensible properties [PMID: 11062264].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.