PLAC (IPR010909)

Short name: PLAC

Overlapping homologous superfamilies


Domain relationships



The PLAC (protease and lacunin) domain is a six-cysteine region of about 40 residues that is present at or near the C-terminal of various enzymes and matrix proteins, including: mammalian PACE4 (paired basic amino acid cleaving enzyme 4), mammalian PCSK5 (proprotein convertase subtilisin/kexin type 5), mammalian metalloproteinases ADAMTS-2, -3, -10, -12, -14, -16, -17, and -19, and manduca Sexta matrix protein lacunin [PMID: 11867212]. The PLAC domain is often associated with other domains, such as the thrombospondin type I repeat (TSP1) (IPR000884), the Kunitz proteinase inhibitor domain (IPR002223), the Ig-like domain (IPR007110), the WAP domain (IPR008197), the subtilase domain (IPR000209), or the ADAM-type metalloprotease domain (IPR001590).

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008233 peptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles