Pathways & interactions
Interleukin-17 family (IPR010345)
Short name: IL-17_fam
Overlapping homologous superfamilies
- Cystine-knot cytokine (IPR029034)
- Interleukin-17 family (IPR010345)
- Interleukin-17, chordata (IPR020440)
Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells.
Interleukin-17 (IL-17) is a potent proinflammatory cytokine produced by activated memory T cells [PMID: 11781375]. The IL-17 family (of which there are 6 known members, termed IL-17A to IL-17F) is thought to represent a distinct signalling system that appears to have been highly conserved across vertebrate evolution [PMID: 11781375]. Family members play an active role in inflammatory diseases, autoimmune diseases and cancer [PMID: 15485625].
This entry represents interleukin-17 family IL-17A to IL-17F. Interleukin-17E has been renamed as interleukin-25 (IL-25). The orthologue from the nematode Caenorhabditis elegans, known as interleukin cytokine-related protein 17.1, is a neuromodulator of sensory responses, and the ligand for the receptor complex composed of ilcr-1 and ilcr-2 [PMID: 28099418].
- PF06083 (IL17)