TPX2 (IPR009675)

Short name: TPX2_fam

Overlapping homologous superfamilies


Family relationships



This family represents the eukaryotic targeting protein for Xklp2 (TPX2). TPX2 is a microtubule-associated protein that targets a plus end-directed motor (Xklp2) to the minus ends of microtubules in the mitotic spindle. In Xenopus, it has been shown that Xklp2 protein is required for centrosome separation and maintenance of spindle bi-polarity [PMID: 8548825]. It is phosphorylated during mitosis in a microtubule-dependent way [PMID: 10871281]. TPX2 activates Aurora A kinase by promoting its autophosphorylation and protects the phosphorylated residue against dephosphorylation [PMID: 18663142].

GO terms

Biological Process

GO:0032147 activation of protein kinase activity
GO:0060236 regulation of mitotic spindle organization

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005874 microtubule
GO:0005819 spindle

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.