Bacteriophage DNA replication protein Gp16.7 (IPR009595)

Short name: Phage_DNA_replic_GP16.7

Overlapping homologous superfamilies

Family relationships



The early-expressed gene 16.7 is conserved in bacteriophage phi-29 and related phages. It encodes a membrane protein, GP16.7, consisting of an N-terminal transmembrane domain and a C-terminal DNA-binding and dimerisation domain. GP16.7 plays an important role in organising membrane-associated bacteriophage DNA replication [PMID: 10921898, PMID: 11169113]. The C-terminal domain has a similar secondary structure similar to homeodomains, but forms a fundamentally different tertiary structure consisting of a six-helical dimeric fold [PMID: 15772069]. Multimerisation of this dimer leads to efficient DNA binding.

GO terms

Biological Process

GO:0039693 viral DNA genome replication

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.