Ryanodine Receptor TM 4-6 (IPR009460)

Short name: Ryanrecept_TM4-6

Overlapping homologous superfamilies


Domain relationships



The release of Ca2+ ions from intracellular stores is a key step in a wide variety of cellular functions. In striated muscle, the release of Ca2+ from the sarcoplasmic reticulum (SR) leads to muscle contraction. Ca2+ release occurs through large, high-conductance Ca2+ release channels, also known as ryanodine receptors (RyRs) because they bind the plant alkaloid ryanodine with high affinity and specificity [PMID: 15110152].

This region covers TM regions 4-6 of the ryanodine receptor 1 family.

GO terms

Biological Process

GO:0006874 cellular calcium ion homeostasis

Molecular Function

GO:0005219 ryanodine-sensitive calcium-release channel activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.