Fructose-1,6-bisphosphatase class 3 (IPR009164)

Short name: FBPtase_class3

Overlapping homologous superfamilies


Family relationships



Fructose 1,6-bisphosphatase catalyses the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate [PMID: 3008716]. This is an essential reaction in the process of gluconeogenesis, the process by which non-carbohydrate precursors are converted to glucose, and hence this enzyme is found almost universally. Enzyme activity can be regulated by a number of different mechanisms including AMP inhibition, cylic AMP-dependent phosphorylation and light-dependent-activation.

This entry represents the class 3 fructose 1,6-bisphosphatases [PMID: 19270101]. The Bacillus subtilis enzyme is inhibited by AMP, though this can be overcome by phosphoenolpyruvate, and is dependent on Mn(2+) [PMID: 221467, PMID: 9696785]. Mutants lacking this enzyme are apparently still able to grow on gluconeogenic growth substrates such as malate and glycerol.

GO terms

Biological Process

GO:0006094 gluconeogenesis

Molecular Function

GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.