Family

Homoserine/serine acetyltransferase MetX-like (IPR008220)

Short name: HAT_MetX-like

Overlapping homologous superfamilies

Family relationships

None.

Description

Homoserine acetyltransferase (homoserine transacetylase) catalyses the first step unique to methionine biosynthesis, converting L-homoserine to O-acetyl-L-homoserine using acetyl-CoA as an acetyl group donor [PMID: 10913262]. This enzyme regulates homoserine in a number of biosynthetic pathways, making it vital to cell growth and viability. The biosynthesis of methionine in particular has been shown to be susceptible to small-molecule inhibition in fungi and is consequently a good candidate for antifungal agents [PMID: 17353245].

This family also includes serine O-acetyltransferases, involved in cysteine biosynthesis [PMID: 11021945], and deacetylcephalosporin C acetyltransferase CefG, closely related to homoserine O-acetyltransferase and involved in cephalosporin biosynthesis [PMID: 1569032].

GO terms

Biological Process

GO:0009058 biosynthetic process

Molecular Function

GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
PIRSF
HAMAP
TIGRFAMs