Tumor necrosis factor ligand superfamily member 15 (IPR008064)

Short name: TNFSF15

Overlapping homologous superfamilies

Family relationships



Tumor necrosis factor ligand superfamily member 15 (TNFSF15) is a receptor for TNFRSF25 and TNFRSF6B. It mediates activation of NF-kappa-B and inhibits vascular endothelial growth and angiogenesis (in vitro). It also promotes activation of caspases and apoptosis [PMID: 11923219].

GO terms

Biological Process

GO:0006915 apoptotic process
GO:0006955 immune response
GO:0007165 signal transduction

Molecular Function

GO:0005164 tumor necrosis factor receptor binding

Cellular Component

GO:0005576 extracellular region
GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.