Domain

CFA20 domain (IPR007714)

Short name: CFA20_dom

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This domain is characteristic of cilia- and flagella-associated protein 20 (CFA20). CFA20 is a cilium- and flagellum-specific protein that plays a role in axonemal structure organisation and motility [PMID: 20118210, PMID: 24574454]. In Chlamydomonas reinhardtii, it stabilises outer doublet microtubules (DMTs) of the axoneme and may work as a scaffold for intratubular proteins, such as tektin and PACRG, to produce the beak structures in DMT1 [PMID: 24259666, PMID: 24574454].

Other proteins contain a domain with homology to CFA20. WDR90/POC16 contains such a domain in its N terminus, followed by a large C-terminal domain with multiple WD40 repeats [PMID: 24574454]. This domain is also present in the N terminus of uncharacterised protein C3orf67.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam