Family

Lantibiotic, type A, Lactobacillales-type (IPR007682)

Short name: Lantibiotic_typ-A_Lactobact

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Lantibiotics are heavily-modified bacteriocin-like peptides from Gram-positive bacteria. They contain alpha,beta-unsaturated amino acids (dehydroalanine and dehydrobutyrine) and lanthionine or 3-methyllanthionine rings (collectively known as thioether rings). There are 2 types of lantibiotic:

  1. Type A (which include nisin, subtilin, epidermin, gallidermin and Pep5) are strongly cationic and bactericidal - nisin, subtilin and Pep5 inhibit the growth of Gram-positive bacteria, probably by voltage-dependent pore formation in the cytoplasmic membrane, resulting in cellular efflux of electrolytes, amino acids and ATP;
  2. Type B lantibiotics possess at most one positive charge and are not bactericidal.

This entry represents type A Lantibiotics that are mostly from Lactobacillales.

GO terms

Biological Process

GO:0042742 defense response to bacterium

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam