Protein of unknown function DUF541 (IPR007497)

Short name: DUF541

Overlapping homologous superfamilies


Family relationships


Members of this family have been found in bacteria, archaea and animals. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase). SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity [PMID: 11096118]. Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerisation. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics [PMID: 11207567]. In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.