Domain

Radical SAM (IPR007197)

Short name: rSAM

Overlapping homologous superfamilies

Domain relationships

Description

Radical SAM proteins catalyze diverse reactions, including unusual methylations, isomerization, sulphur insertion, ring formation, anaerobic oxidation and protein radical formation. Evidence exists that these proteins generate a radical species by reductive cleavage of S:-adenosylmethionine (SAM) through an unusual Fe-S centre [PMID: 11222759, PMID: 15317939].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003824 catalytic activity
GO:0051536 iron-sulfur cluster binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SFLD