Molybdopterin oxidoreductase, 4Fe-4S domain (IPR006963)

Short name: Mopterin_OxRdtase_4Fe-4S_dom

Overlapping homologous superfamilies


Domain relationships



The molybdopterin oxidoreductase 4Fe-4S domain is found in a number of reductase/dehydrogenase families, which include the periplasmic nitrate reductase precursor and the formate dehydrogenase alpha chain [PMID: 9036855].

The following proteins contain this domain and belong to the molybdenium (Mo) or tungsten (W) containing enzyme family, the Mo/W bis-MGD (molybdopterin-guanine-dinucleotide) oxydoreductases [PMID: 2015248, PMID: 3062312, PMID: 8125918]:

  • Escherichia coli respiratory nitrate reductase (EC:
  • Escherichia coli anaerobic dimethyl sulfoxide reductase (DMSO reductase).
  • Escherichia coli biotin sulfoxide reductases (genes bisC and bisZ).
  • Methanobacterium formicicum formate dehydrogenase (EC:
  • Escherichia coli formate dehydrogenases -H (gene fdhF), -N (gene fdnG) and -O (gene fdoG).
  • Wolinella succinogenes polysulfide reductase chain.
  • Salmonella typhimurium thiosulfate reductase (gene phsA).
  • Escherichia coli trimethylamine-N-oxide reductase (EC: (gene torA) [PMID: 8022286].
  • Nitrate reductase (EC: from Klebsiella pneumoniae (gene nasA), Alcaligenes eutrophus, Escherichia coli, Rhodobacter sphaeroides, Thiosphaera pantotropha (gene napA), and Synechococcus PCC 7942 (gene narB).

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles