HD domain (IPR006674)

Short name: HD_domain

Overlapping homologous superfamilies

Domain relationships


The HD domain is found in a superfamily of enzymes with a predicted or known phosphohydrolase activity [PMID: 17951247]. These enzymes appear to be involved in the nucleic acid metabolism, signal transduction and possibly other functions in bacteria, archaea and eukaryotes. The fact that all the highly conserved residues in the HD superfamily are histidines or aspartates suggests that coordination of divalent cations is essential for the activity of these proteins [PMID: 9868367].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.