Pyrimidine 5'-nucleotidase, eukaryotic (IPR006434)

Short name: Pyrimidine_nucleotidase_eu

Overlapping homologous superfamilies

Family relationships



This family is a small group of metazoan sequences with sequences from Arabidopsis thaliana (Mouse-ear cress) and rice. The sequences represent pyrimidine 5-nucleotidases, apparently in reference to HSPC233, the Homo sapiens (Human) homologue [PMID: 10942414]. The structure of mouse sequence has been reported [PMID: 16672222]. This group of sequences was originally found during searches for members of the haloacid dehalogenase (HAD) superfamily. All of the conserved catalytic motifs [PMID: 7966317] are found. The placement of the variable domain between motifs 1 and 2 indicates membership in subfamily I of the superfamily, but these sequences are sufficiently different from any of the branches of that subfamily (IA-ID) as to constitute a separate branch to now be called IE. Considering that the closest identifiable hit outside of the noise range is to a phosphoserine phosphatase, this group may be considered to be most closely allied to subfamily IB.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008253 5'-nucleotidase activity
GO:0000287 magnesium ion binding

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.