Periplasmic solute binding protein, ZnuA-like (IPR006127)

Short name: ZnuA-like

Overlapping homologous superfamilies


Family relationships


Members of this family constitute the solute-binding protein component of cluster-9 ABC transporters. This family includes periplasmic solute binding protein TroA from Treponema pallidum, which binds Zn2+ and Mn2+ [PMID: 17581125]. In Streptococcus suis, TroA is required for manganese acquisition [PMID: 21784944]. Related proteins are found in both Gram-positive and Gram-negative bacteria, including manganese-binding lipoprotein MntA [PMID: 16194238] and high-affinity zinc uptake system protein ZnuA [PMID: 24128931].

ZnuA is part of the bacterial zinc-uptake complex ZnuABC. ZinT acts as a Zn2+-buffering protein that delivers Zn2+ to ZnuA, a high-affinity zinc-uptake protein. In Gram-negative bacteria the ZnuABC transporter system ensures an adequate import of zinc in Zn2+-poor environments, such as those encountered by pathogens within the infected host [PMID: 21338480, PMID: 24128931].

GO terms

Biological Process

GO:0030001 metal ion transport

Molecular Function

GO:0046872 metal ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.