Resolvase, HTH domain (IPR006120)

Short name: Resolvase_HTH_dom

Overlapping homologous superfamilies


Domain relationships



Site-specific recombination plays an important role in DNA rearrangement in prokaryotic organisms. Two types of site-specific recombination are known to occur:

  1. Recombination between inverted repeats resulting in the reversal of a DNA segment.
  2. Recombination between repeat sequences on two DNA molecules resulting in their cointegration, or between repeats on one DNA molecule resulting in the excision of a DNA fragment.

Site-specific recombination is characterised by a strand exchange mechanism that requires no DNA synthesis or high energy cofactor; the phosphodiester bond energy is conserved in a phospho-protein linkage during strand cleavage and re-ligation.

Two unrelated families of recombinases are currently known [PMID: 3011407]. The first, called the 'phage integrase' family, groups a number of bacterial phage and yeast plasmid enzymes. The second [PMID: 2896291], called the 'resolvase' family, groups enzymes which share the following structural characteristics: an N-terminal catalytic and dimerization domain that contains a conserved serine residue involved in the transient covalent attachment to DNA IPR006119, and a C-terminal helix-turn-helix DNA-binding domain.

GO terms

Biological Process

GO:0006310 DNA recombination

Molecular Function

GO:0003677 DNA binding
GO:0000150 recombinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.