Type I L-asparaginase family (IPR006033)

Short name: AsnA_fam

Overlapping homologous superfamilies

Family relationships


Two related families of asparaginase are designated type I and type II according to the terminology in Escherichia coli, which has both: L-asparaginase I is a low-affinity enzyme found in the cytoplasm, while L-asparaginase II is a high-affinity secreted enzyme synthesized with a cleavable signal sequence. This family includes L-asparaginases related to type I of E. coli. Archaeal members of this family contain an extra ~80 residues in a conserved N-terminal region. These archaeal homologues are known as GATD (glutamyl-tRNA(Gln) amidotransferase subunit D) [PMID: 16809540].

GO terms

Biological Process

GO:0006520 cellular amino acid metabolic process

Molecular Function

GO:0004067 asparaginase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.