Tryptophan 5-monooxygenase (IPR005963)

Short name: Trp_5_mOase

Overlapping homologous superfamilies

Family relationships


Tryptophan 5-monooxygenase (EC: is a member of the family of tetrameric, biopterin-dependent aromatic amino acid hydroxylases found in metazoans. It is closely related to tetrameric phenylalanine-4-hydroxylase and tyrosine 3-monooxygenase, and more distantly related to the monomeric phenylalanine-4-hydroxylase found in some Gram-negative bacteria. It is the rate-limiting enzyme in the biosynthesis of serotonin in the central nervous system and catalyzes the first step of the synthesis of melatonin in the pineal gland [PMID: 11472242]. L-tryptophan + tetrahydropteridine + O2 = 5-hydroxy-L-tryptophan + dihydropteridine + H2O

GO terms

Biological Process

GO:0055114 oxidation-reduction process
GO:0042427 serotonin biosynthetic process

Molecular Function

GO:0004510 tryptophan 5-monooxygenase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.