Pyruvate carboxylase (IPR005930)

Short name: Pyruv_COase

Overlapping homologous superfamilies

Family relationships



In the postabsorptive state, blood glucose concentration is kept constant by a combination of glycogenolysis and gluconeogenesis. During prolonged fasting, when hepatic glycogen is exhausted, gluconeogenesis becomes the only source of plasma glucose. Gluconeogenesis (the production of new glucose molecules) occurs mainly in liver and, to a small extent, in kidneys.

Pyruvate carboxylase (EC:, a member of the biotin-dependent enzyme family, catalyses the ATP-dependent carboxylation of pyruvate to oxaloacetate, thus playing a crucial role in gluconeogenesis. ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate Most well characterised forms of active enzyme consist of four identical subunits arranged in a tetrahedron-like structure. Each subunit contains three functional domains: the biotin carboxylation domain, the transcarboxylation domain and the biotin carboxyl carrier domain.

GO terms

Biological Process

GO:0006094 gluconeogenesis
GO:0006090 pyruvate metabolic process

Molecular Function

GO:0005524 ATP binding
GO:0009374 biotin binding
GO:0004736 pyruvate carboxylase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.