Protein disulphide isomerase (IPR005792)

Short name: Prot_disulphide_isomerase

Overlapping homologous superfamilies

Family relationships


This family represents eukaryotic protein disulphide isomerases retained in the endoplasmic reticulum (ER) and other closely related forms [PMID: 12384992]. Some members have been assigned alternative or additional functions such as prolyl 4-hydroxylase [PMID: 2846539, PMID: 10597631]. Members of this family have at least two protein-disulphide domains, each similar to thioredoxin but with the redox-active disulphide in the motif PWCGHCK, and an ER retention signal at the extreme C terminus (KDEL, HDEL, and similar motifs).

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003756 protein disulfide isomerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.