Dihydroorotate dehydrogenase domain (IPR005720)

Short name: Dihydroorotate_DH

Overlapping homologous superfamilies

Domain relationships



Dihydroorotate dehydrogenase (EC: (DHOdehase) catalyzes the fourth step in the de novo biosynthesis of pyrimidine, the conversion of dihydroorotate into orotate. DHOdehase is a ubiquitous FAD flavoprotein. In bacteria (gene pyrD), DHOdease is located on the inner side of the cytosolic membrane. In some yeasts, such as in Saccharomyces cerevisiae (gene URA1, subfamily 2), it is a cytosolic protein while in other eukaryotes it is found in the mitochondria [PMID: 1409592].

This entry represents a domain found in the type I dihydroorotate dehydrogenases and dihydropyrimidine dehydrogenase.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.