Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase (IPR005715)

Short name: Glu_5kinase/COase_Synthase

Overlapping homologous superfamilies

Family relationships


L-glutamate 5-phosphotransferase, (gamma-glutamyl kinase, proB, EC:, catalyzes the first step in proline biosynthesis ATP + L-glutamate = ADP + L-glutamate 5-phosphate. the product of which rapidly cyclises to 5-oxoproline and phosphate.

This entry also includes delta-1-pyrroline-5-carboxylate synthase, an enzyme that in the N-terminal section belongs to the glutamate 5-kinase family. Glutamate 5-kinase hits the full length of this model, but delta 1-pyrroline-5-carboxylate synthetase does not hit the C-terminal 100 residues.

GO terms

Biological Process

GO:0006561 proline biosynthetic process

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.