DNA gyrase inhibitor YacG (IPR005584)

Short name: DNA_gyrase_inhibitor_YacG

Overlapping homologous superfamilies

Family relationships



This entry represents the DNA gyrase inhibitor YacG family. E coli. YacG inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. It acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase [PMID: 18586829]. YacG has been shown to bind zinc and contains the structural motifs typical of zinc-binding proteins [PMID: 12211008]. The conserved four cysteine motif in this protein (-C-X(2)-C-X(15)-C-X(3)-C-) is not found in other zinc-binding proteins with known structures.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008270 zinc ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.