Transcription factor GRAS (IPR005202)

Short name: TF_GRAS

Overlapping homologous superfamilies


Domain relationships



Sequence analysis of the products of the GRAS (GAI, RGA, SCR) gene family indicates that they share a variable N terminus and a highly conserved C terminus that contains five recognizable motifs [PMID: 10341448]. Proteins in the GRAS family are major players in gibberellin (GA) signaling, which regulates various aspects of plant growth and development [PMID: 10341448]. Mutation of the SCARECROW (SCR) gene results in a radial pattern defect, loss of a ground tissue layer, in the root. The PAT1 protein is involved in phytochrome A signal transduction [PMID: 10817761].

A sequence, structure and evolutionary analysis showed that the GRAS family emerged in bacteria and belongs to the Rossmann-fold, AdoMET (SAM)-dependent methyltransferase superfamily [PMID: 22829623]. All bacterial, and a subset of plant GRAS proteins, are predicted to be active and function as small-molecule methylases. Several plant GRAS proteins lack one or more AdoMet (SAM)-binding residues while preserving their substrate-binding residues. Although GRAS proteins are implicated to function as transcriptional factors, the above analysis suggests that they instead might either modify or bind small molecules [PMID: 22829623].

    Some proteins known to belong to the GRAS family are listed below:
  • Arabidopsis thaliana SCARECROW (SCR) protein. It regulates asymetric cell divisions of cortex/endodermal initial cells during root development.
  • Arabidopsis thaliana SCARECROW-LIKE (SCL) protein.
  • Arabidopsis thaliana GIBBERELLIN-ACID INSENSITIVE (GAI) and REPRESSOR OF GA1 (RGA), two closely related proteins involved in gibberellin signaling.
  • Arabidopsis thaliana SHORT ROOT (SHR) protein. It is necessary for cell division and endodermis specification.
  • Arabidopsis thaliana PAT1 protein. It inhibits light signaling via the phytochrome A (phyA).
  • LATERAL SUPPRESSOR (LS), a protein from tomato that controls the formation of lateral branches during vegetative development.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles