Calcium/proton exchanger (IPR004713)

Short name: CaH_exchang

Overlapping homologous superfamilies


Family relationships


Proteins of the Ca2+:Cation Antiporter (CaCA) family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria. All of the characterised animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The Escherichia coli ChaA protein catalyses Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterised members of the family catalyze Ca2+:H+ exchange.

GO terms

Biological Process

GO:0006812 cation transport
GO:0055085 transmembrane transport

Molecular Function

GO:0008324 cation transmembrane transporter activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.