Ribosomal S6 modification enzyme RimK/Lysine biosynthesis enzyme LysX (IPR004666)

Short name: RpS6_RimK/Lys_biosynth_LsyX

Overlapping homologous superfamilies

Family relationships


Escherichia coli RimK adds additional Glu residues to the native Glu-Glu C terminus of ribosomal protein S6. Mutation of the Glu-Glu terminus to Lys-Glu blocked addition. S6 has the C-terminal sequence Glu-Glu in few species, suggesting the homologue of rimK may have a function other than S6 modification in those species. However, most species having a member of this protein subfamily do not have an S6 homologue ending in Glu-Glu.

The family of proteins found in this family include the characterised LysX from Thermus thermophilus [PMID: 12963379] which is part of a well-organised lysine biosynthesis gene cluster [PMID: 10613839]. LysX is believed to carry out an ATP-dependent acylation of the amino group of alpha-aminoadipate in the prokaryotic version of the fungal AAA lysine biosynthesis pathway. No species having a sequence in this family contains the elements of the more common diaminopimelate lysine biosythesis pathway, and none has been shown to be a lysine auxotroph. These sequences have mainly recieved the name of the related enzyme, "ribosomal protein S6 modification protein RimK". RimK has been characterised in Escherichia coli, and acts by ATP-dependent condensation of S6 with glutamate residues [PMID: 2570347].

GO terms

Biological Process

GO:0006464 cellular protein modification process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.