Aspartate-tRNA ligase, type 1 (IPR004524)

Short name: Asp-tRNA-ligase_1

Overlapping homologous superfamilies

Family relationships


Aspartate tRNA ligase (also known as Aspartyl-tRNA synthetase) EC: is an alpha2 dimer that belongs to class IIb. Structural analysis combined with mutagenesis and enzymology data on the yeast enzyme point to a tRNA binding process that starts by a recognition event between the tRNA anticodon loop and the ligase anticodon binding module [PMID: 10873455].

This family represents aspartate-tRNA ligases from mostly bacterial and eukaryotic mitochondria. In some species, this enzyme aminoacylates tRNA for both Asp and Asn; Asp-tRNA(asn) is subsequently transamidated to Asn-tRNA(asn).

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005524 ATP binding
GO:0016874 ligase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.